The First Affliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 156
- 主要终点
- Detection of lncRNA SNHG15 in HBV-associated HCC patients before surgery
研究概览
简要总结
In this study, the investigators will detect the expression of HBV-related HCC biomarker lncRNA SNHG15 in tumor tissues and peripheral blood, to explore the specific molecular markers for the early diagnosis of HBV-related HCC.
详细描述
Paired hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and adjacent liver tissues were selected, and lncRNA SNHG15 was detected by RT-PCR. At the same time, healthy subjects were selected as the control group, and lncRNA SNHG15 in blood was detected by RT-PCR. At the same time, the correlation between lncRNA SNHG15 and the clinical data of patients, such as diagnosis, pathological grading, recurrence, metastasis and survival time was statistically analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The age and sex of the healthy control group were matched with that of HBV-associated patient group. There was no tumor in the other parts of the body, and no tumor in the blood system. The healthy control group did not have any liver benign diseases. There are no inflammatory diseases in other parts of the body; the functions of the liver, kidney, and heart were normal.
排除标准
- •The volunteer has tumors in the liver or other parts of the body, or blood system tumors; The volunteer has benign liver diseases; The patient has inflammatory disease elsewhere. If the volunteer has any one of the above diseases, it shall be excluded.
结局指标
主要结局
Detection of lncRNA SNHG15 in HBV-associated HCC patients before surgery
时间窗: 1 to 3 days before surgery
The expression of lncRNA SNHG15 in blood samples: The expressions of lncRNA SNHG15 in blood samples were detected by real-time fluorescence quantitative PCR method.
次要结局
- Detection of lncRNA SNHG15 in HBV-associated HCC patients 1 week after surgery(one week after surgery)
- Detection of lncRNA SNHG15 in HBV-associated HCC patients at 6 months after surgery(6 months postoperatively)
- Detection of lncRNA SNHG15 in the control groups as baseline(the level of lncRNA SNHG15 were detected as baseline)
研究者
ChunqingWang
Intermediate technician
Qianfoshan Hospital