CTRI/2010/091/000451未知不适用
Application of proteomics to aid biomarker discovery in smear positive patients of P.vivax and P.falciparum malaria
Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT), Powai, Mumbai- 400 0761 个研究点 分布在 1 个国家目标入组 100 人开始时间: 待定
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To obtain the global proteome profile of P. falciparum and P.vivax
研究概览
简要总结
This is a prospective study wherein 50 patients with smear positive for P. vivax and 50 with smear positive for P. falciparum will be enrolled. Thereafter 5 ml of heparinized blood sample will be collected and stored at -20 degree celsius pending proteomic analysis. The primary outcome is to to obtain the global proteome profile and compare the proteomic profile of P. vivax versus P. falciparum malaria. This will help in biomarker discovery for malaria.
研究设计
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
入选标准
- •Patients of either sex, aged 18-65 years both inclusive
- •Patients with P.
- •vivax or P.
- •falciparum parasitemia more than 1000 parasites/microliter
- •Those willing to provide written informed consent and comply with protocol requirements.
排除标准
- •Patients with history of significant systemic diseases like autoimmune disorders, chronic liver diseases, psychiatric illness and bleeding disorders etc.
- •as judged by history and physical examination.
- •Severe/complicated malaria as per WHO criteria
- •Subjects unwilling to consent for the study
- •Malaria patients having mixed infection (both P.vivax and P.falciparum) in peripheral smear.
结局指标
主要结局
To obtain the global proteome profile of P. falciparum and P.vivax
时间窗: 6 months
次要结局
未报告次要终点
研究者
研究点 (1)
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