NCT02161666已完成不适用
Effect of Gastric Bypass Surgery on Pancreatic Islet and Incretin Function - Follow-up Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Change in islet cell function from baseline (preoperatively)
研究概览
简要总结
To examine pancreatic islet function and incretin function during intravenous and oral stimulation >2 years after gastric bypass surgery in patients with normal glucose tolerance. We hypothesize that islet cell and incretin function is enhanced in response to oral, but not intravenous, stimulation - i.e. incretin released from the gut in response to oral stimulation play a key role for the enhanced islet function after gastric bypass surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participation in previous study (NCT01559779)
排除标准
- •Pregnancy/lactation
- •Major chronic disease develop since previous examination with possible impact on outcomes
结局指标
主要结局
Change in islet cell function from baseline (preoperatively)
时间窗: >24 months
Change in insulin and glucagon secretion during oral and intravenous stimulation after gastric bypass
次要结局
- Change in glucose tolerance during oral glucose tolerance test(>24 months)
- Arterio-venous glucose difference during oral glucose tolerance test after gastric bypass(>24 months)
研究者
Carsten Dirksen
MD, PhD
Hvidovre University Hospital
研究点 (1)
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