Cognitive Impairment After Critical Illness, Links Between Sepsis, Cognitive Function and Non-resolving Inflammation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Is HMGB1 elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice?
研究概览
简要总结
Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male/Female age 18-17
- •Expected ICU-stay more than 24 hours
排除标准
- •Dont understand the language
- •Substance abuse, alcohol or drugs
- •Blind, deaf or suffering from aphasia
- •Ongoing psychiatric illness or psychopharmacological treatment
- •Suffering from dementia och mentally impaired
- •Structured brain damage or meningitis
- •Palliative Care
- •ICU-treated for more than 48 hours
- •Transferred from other ICU
- •Being treated with ECMO
- •Not having residency in Stockholm
结局指标
主要结局
Is HMGB1 elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice?
时间窗: 2 years
Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?
时间窗: 4 years
次要结局
未报告次要终点
研究者
Peter Sackey
MD, PhD
Karolinska University Hospital