Metabolic Dynamics During Physical Activity Under Normobaric Normoxia or Moderate Hypoxia - a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Change in capillary lactate/pyruvate Ratio (dimension-free)
研究概览
简要总结
The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on metabolites and metabolic pattern related to energy metabolism. The metabolome analyses in capillary blood could give us also or more detailed insight into erythrocyte metabolic physiology because it is known for a longer time that the primary metabolism of the erythrocyte reflects its Oxygen Saturation via the glycolytic metabolites / intermediates pattern.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
- •written informed consent
排除标准
- •known cardio-vascular, lung, metabolic, endocrine, hematologic, kidney or neurologic diseases
- •pregnancy, lactating period
- •unability to understand study content and aims and to give written informed consent
研究组 & 干预措施
running under hypoxia - first
running under hypoxia (first day) and normoxia (second day)
干预措施: running on a treadmill under normoxia or hypoxia (Other)
running under normoxia - first
running under normoxia (first day) and hypoxia (second day)
干预措施: running on a treadmill under normoxia or hypoxia (Other)
结局指标
主要结局
Change in capillary lactate/pyruvate Ratio (dimension-free)
时间窗: t = 0 min (before exercise); t = 10, 20 and 30 min during exercise; t = 50 and 60 min during recovery
marker for the ratio between anaerobic / aerobic glycolysis
次要结局
未报告次要终点
研究者
Michael Boschmann
Dr. Michael Boschmann
Charite University, Berlin, Germany