Dynamic PET CT as a Tool for Treatment Efficacy Monitoring in Lung Cancer
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Compare baseline PET-CT with PET-CT after 7-14 days.
研究概览
简要总结
The purpose of this study is to evaluate the use of Dynamic PET/CT as a tool to assess disease response to anti-cancer therapy in Lung Cancer patients.
详细描述
Background:
Lung cancer is a devastating disease in which the response for first line therapy is only 30%. Evaluating response is performed normally by a CT or PET-CT scans after 2-3 cycles of therapy, thus, lack of response is been evaluated only after the patient has been treated following significant amount of therapy, which is inefficient in 70% of cases.
Therefore, there is an urgent need to develop tools that might predict response to therapy during the early course of therapy; Most valuable will be before or after the first cycle of therapy. For that reason, the investigators aim in this study to evaluate the use of Dynamic PET-CT as a tool to assess disease response to anti-cancer therapy in Lung Cancer patients.
Objectives:
- To assess the feasibility of baseline Dynamic PET-CT as a tool for assessing response for anti-cancer therapy in Lung Cancer patients.
- To predict early response to treatment as soon as after 1 cycle of therapy by dynamic and static PET-CT.
- To correlate Dynamic PET-CT with survival/disease free survival
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years.
- •Lung cancer, stage 4
- •Patients are planned to be treated by a systemic anti-cancer therapy.
- •A define lesion for imaging.
- •Able and willing to sign an informed consent form.
- •First line therapy or at least 6 weeks after previous line of therapy
排除标准
- •Pregnant or lactating women.
- •Anti cancer therapy within the last 6 weeks before enrollment.
结局指标
主要结局
Compare baseline PET-CT with PET-CT after 7-14 days.
时间窗: 12 months
次要结局
- Measuring response to treatment by PET-CT.(12 months)
- Evaluate overall survival rate (OS) in lung cancer by using dynamic PET-CT.(12 months)
- Evaluate disease-free survival (DFS) in lung cancer by using dynamic PET-CT.(12 months)
研究者
Nir Peled
Professor
Rabin Medical Center