Screening Expiratory Flow Limitation by Flow-time Curve
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Outcome (Presence / absence of EFL) will be determined by off-line analysis of recorded flow-volume loops during PEEP reduction.
研究概览
简要总结
Expiratory flow limitation (EFL) is defined as a dynamic condition that expiratory flow cannot be further increased with higher expiratory driving pressure. Under mechanical ventilation, it can cause intrinsic positive end-expiratory pressure (PEEP) and dynamic hyperinflation, and be associated with worse clinical outcome. The detection of EFL however needs special maneuvers and offline analysis of flow-volume curves, which are infeasible in routine practice and cannot be used during real-time monitoring. The investigators propose a new and simple approach using flow derived parameters to detect EFL in real time without needing any intervention.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years, intubated or tracheostomized
- •Receiving invasive mechanical ventilation in assist/control mode with PEEP ≥ 5 cmH2O
- •Receiving continuous intravenous sedation
- •Displaying a monotonous regular breathing pattern with no obvious asynchrony
排除标准
- •Severe hypoxemia in baseline clinical ventilator settings (SpO2 < 90%)
- •Hemodynamic instability (mABP <60 mmHg, systolic arterial pressure >180 mmHg, heart rate <40/min or >150/min)
结局指标
主要结局
Outcome (Presence / absence of EFL) will be determined by off-line analysis of recorded flow-volume loops during PEEP reduction.
时间窗: 2 years
次要结局
- Percentage of intrinsic PEEP caused by the EFL.(2 years)