CTRI/2020/10/028294已完成未知
EVALUATION OF PCSK9 AND IL-6 LEVELS IN SERUM AND SALIVA OF PATIENTS WITH ATHEROMATOUS PLAQUE WITH AND WITHOUT PERIODONTITIS.
Roshan R Rughwani0 个研究点目标入组 76 人开始时间: 待定最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 76
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Inclusion criteria common to all groups:
- •1.Age range: >=35.
- •2.Non Smoker.
- •Based on 2017 World Workshop on the Classification of Periodontal and Peri-implant diseases and conditions, co-presented by the American Academy of Periodontology (AAP) and the European Federation of Periodontology(EFP),
- •Inclusion criteria for periodontally healthy individuals:
- •According to the new classification scheme (Kornman and Tonetti et al, 2018).
- •1.Pristine periodontal health(No bleeding on probing,Normal gingival sulcus depth,Normal bone heights,Controlled modifying factors,Controlled predisposing factors.
- •2.Clinical periodontal health (intact periodontium):No or minimal bleeding on probing,Normal gingival sulcus depth,Normal bone heights,Controlled modifying factors,Controlled predisposing factors.
- •Inclusion criteria for Stage III/IV Periodontitis:
- •According to the new classification scheme (Kornman and Tonetti et al, 2018).
- •1.Stage III:Interdental clinical attachment loss at site of greatest loss >= 5mm,Radiographic bone loss extending to middle or apical third of root,Tooth loss due to periodontitis <= 4 teeth,Probing depth >= 6mm,Extent: Greater than 30% of teeth involved (Generalized)
- •2.Stage IV:Interdental clinical attachment loss at site of greatest loss >= 5mm,Radiographic bone loss extending to middle or apical third of root,Tooth loss due to periodontitis >= 5 teeth,Extent: Greater than 30% of teeth involved (Generalized)
- •Inclusion criteria for Atherosclerotic patients:
- •1.History of angina
- •2.Angiography revealing a block.
- •3.Raised serum LDL and triglyceride levels
- •LDL Cholesterol Level:
- •160 to 189 mg/dl (High)
- •>190 mg/dl (Very High)
- •Total Cholesterol Level: greater than 240 mg/dl
- •Non HDL Cholesterol level above 159 mg/dl
- •Triglyceride levels : 200 to 499 mg/dl (High)
- •Above 500 mg/dl(Very High)
排除标准
- •1.Patients with immunodeficiency disorders.
- •2.Patients with other systemic inflammatory conditions like sepsis, pneumonia, pleural effusion, intra-abdominal infections, inflammatory bowel disorders, inflammatory rheumatoid disorders, chronic kidney disease, cancers, diabetes, COPD, asthma, HIV and hepatitis will be excluded from the study.
- •3.History of periodontal treatment within the previous 6 months.
- •4.History of antibiotic therapy in the past 3 months.
- •5.History of consumption of antihypertensive medications - calcium channel blockers.
- •6.Subjects who are not willing to participate in the study.
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