A comparative study between intravenous Clonidine and intravenous Magnesium sulphate in attenuating hemodynamic response to laryngoscopy and intubation a randomised study.
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- To determine the effectiveness of intravenous Clonidine versus intravenous Magnesium sulphate in attenuating the hemodynamic response to laryngoscopy and intubation in patients undergoing surgeries under general anaesthesia.
研究概览
简要总结
This randomised study is designed to study the effectiveness of Intavenous Clonidine versus Intravenous Magnesium sulphate in attenuating the hemodynamic response to laryngoscopy and intubation and also to say which is better with less side effects in patients undergoing surgeries under general anaesthesia.
This study will be carried out in 2 groups of patients who meet inclusion criteria. Patients are randomly allocated into 2 groups of 33 people each using the opaque sealed envelope method. Group C will receive Inj. Clonidine 1mcg/kg in 100 ml NS over 10 mins Group M will receive inj. Magnesium sulphate 30mg/kg in 100 ml NS over 10 mins.
Intra-operatively monitors will be connected, baseline vitals will be noted like SBP, DBP, MAP, SPO2, HR. Rate pressure product will be calculated.
At the end of infusion, induction of anaesthesia will be done with Inj. Propofol 2mg/kg. Followed by vecuronium 0.1mg/kg after recording hemodynamic measurements and ventilation with 100% oxygen. Intubation will be done with cuffed ETT of appropriate size after direct laryngoscopy.
Hemodynamic response will be recorded before giving drug, immediately after giving drug, before induction, after induction followed by 1min, 3 min, 5min and 10 min after intubation.
Any adverse effect during the study will be recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status 1 and
- •Patients undergoing elective surgeries under GA.
- •Patients with BMI less than 30kg/m2 Patients consenting for study.
排除标准
- •Patients with anticipated difficult airway Pregnant and lactating women Patient allergic to study drugs.
结局指标
主要结局
To determine the effectiveness of intravenous Clonidine versus intravenous Magnesium sulphate in attenuating the hemodynamic response to laryngoscopy and intubation in patients undergoing surgeries under general anaesthesia.
时间窗: Intraoperatively drug will be administered and hemodynamic responses will be recorded before giving drug, immediately after giving | drug, just before induction, after induction followed by 1min, 3 min, 5min and 10 min after intubation. | Any adverse effects during study will be noted intraoperatively.
To determine which of the two drugs have less side effects
时间窗: Intraoperatively drug will be administered and hemodynamic responses will be recorded before giving drug, immediately after giving | drug, just before induction, after induction followed by 1min, 3 min, 5min and 10 min after intubation. | Any adverse effects during study will be noted intraoperatively.
次要结局
未报告次要终点
研究者
Dr Kruthi D
Sapthagiri Institute of Medical Sciences and Research Centre