Effects of intraduodenal versus intragastric administration of quinine on gut and gluco-regulatory hormone release, antropyloroduodenal motility, blood glucose concentrations and appetite perceptions, in healthy, lean volunteers.

Christine Feinle-Bisset0 个研究点目标入组 28 人开始时间: 2019年5月10日最近更新: 2021年10月26日

适应症

试验速览

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•Significant gastrointestinal symptoms, disease or surgery;
•Current gallbladder or pancreatic disease;
•Cardiovascular or respiratory diseases; .
•Any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above);
•Use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, gastrointestinal function, body weight or appetite (eg domperidone and cisapride, anticholinergic drugs (eg atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.);
•Individuals with low ferritin levels (less than 30 ng/mL), or who have donated blood in the 12 weeks prior to taking part in the study;
•Lactose intolerance/other food allergy(ies);
•Vegetarians;
•Restrained eaters (score >12 on the three factor eating questionnaire);
•Current intake of greater than 2 standard drinks on greater than 5 days per week;
•Current smokers of cigarettes/cigars/marijuana;
•Current intake of any illicit substance;
•High performance athletes;
•Inability to comprehend study protocol;
•Unable to tolerate naso-gastric tube

发起方