Biomarkers in Saliva in Children With Juvenil Idiopathic Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Biomarkers in saliva, a comparison between healthy children and children with juvenile idiopathic arthritis.
研究概览
简要总结
Purpose and aims This as a pilot study that aims to investigate which inflammatory biomarkers can be found in saliva in children with Juvenile Idiopathic Arthritis (JIA).
The hypothesis is that children with JIA will show a different pattern of inflammatory biomarkers in saliva than healthy Children.
The null hypothesis is that there are no differences.
详细描述
This is a comparison between 100 children with JIA and 100 healthy children. Saliva will be collected and analyzed with respect to biomarkers.
One-hundred consecutive patients with active JIA, as diagnosed by the Department of Pediatric Rheumatology, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital will be included.
Inclusion criteria are:
- age between 7 and 14 years
- a diagnosis of JIA according to the International League of Associations for rheumatology
Exclusion criteria are:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A diagnosis of JIA according to the International League of Associations for rheumatology (ILAR) The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1
排除标准
- •current malignancies
- •TMJ surgery or trauma within two years
- •Recent intra-articular glucocorticoid injection in TMJ (within 1 month)
- •Other conditions or diseases than JIA that may cause orofacial pain. Fore the controllgroup JIA are excluded
结局指标
主要结局
Biomarkers in saliva, a comparison between healthy children and children with juvenile idiopathic arthritis.
时间窗: one day
Saliva sampels will be colleceted and analysed
次要结局
未报告次要终点
研究者
Malin Collin
PhD student, DDS
Folktandvården Stockholms län AB