Neural Predictors of Response to Cognitive Behavioral Therapy for Adolescent Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Clinician-rated improvement
研究概览
简要总结
The current study will examine neurophysiological, specifically event-related potential (ERP), measures of emotional processing as predictors of response to cognitive behavior therapy for adolescent depression.
详细描述
Neurophysiological measures (i.e., event-related potentials) of reward responsiveness and regulation of mood-congruent, sad stimuli will be assessed in a sample of adolescents with depression prior to group cognitive behavior therapy (CBT). CBT will follow the Adolescent Coping with Depression Course, an established 16-session group treatment protocol, and consist of behavioral activation, relaxation skills, cognitive therapy, social skills, problem solving, and relapse prevention. Changes in symptoms will be monitored through biweekly self-report and clinician ratings to examine prediction of change in symptoms across CBT. Baseline individual differences in reward responsiveness and emotion regulation will be evaluated as predictors of change in self-reported symptoms and clinician-rated improvement following CBT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants presenting with major depressive or persistent depressive disorder and moderate severity on the Clinical Global Impressions scale.
- •Participants may have comorbid externalizing or anxiety disorders.
- •Participants (and parents of minors) fluent in English.
排除标准
- •Youth with history of treatment for substance use disorders.
- •Youth with intellectual or developmental disabilities (e.g., autism spectrum disorders, pervasive developmental disorders).
- •Youth with lifetime schizophrenia, psychosis, or mania.
- •Youth with severe current suicidality.
- •Youth taking antipsychotic medications or mood stabilizers.
- •Youth with recent changes in dosage of antidepressant (adolescents with change in dosage in past 30 days who otherwise meet study criteria will be asked to begin the study once dosage has been stable for 30 days).
- •Parent or child not fluent in English.
- •Youth who are unable to complete study procedures because of visual or hearing impairments.
- •Youth who have recently started outside therapy (past 30 days at time of intake), are engaged in treatment that is determined to be too similar to study therapy (e.g, other CBT groups), or are currently in treatment that is too intensive to allow for participation in study therapy (e.g., partial hospitalization programs)
结局指标
主要结局
Clinician-rated improvement
时间窗: 8 weeks
Global improvement rating on the Clinical Global Impression scale
Depressive symptoms
时间窗: past 2 weeks
Self-reported symptoms on the Mood and Feelings Questionnaire
次要结局
未报告次要终点
研究者
Autumn Kujawa
Assistant Professor
Vanderbilt University