Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Ultrasound Changes in Knee Muscle and Tendon
研究概览
简要总结
The aim of this study is to determine the influence of acute resistance exercises on anatomical and biological changes in the quadriceps muscle and tendons of the knee
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-professional athletes
- •Pass heart/lung endurance tests
- •Pass ergometrics testing
排除标准
- •Have been injured
- •Had physiotherapy for back or lower limbs in past 6 months
- •Orthopedic surgery in lower limbs
研究组 & 干预措施
One acute resistance load exercise
One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
干预措施: Percutaneous Needle Core Biopsy (Diagnostic Test)
One acute resistance load exercise
One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
干预措施: Acute resistant load exercises (Other)
One acute resistance load exercise
One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
干预措施: Background Questionnaire (Behavioral)
One acute resistance load exercise
One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
干预措施: Pain Questionnaire (Other)
One acute resistance load exercise
One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
干预措施: DNA and RNA test (Genetic)
One acute resistance load exercise
One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
干预措施: Ultrasound (Diagnostic Test)
Three acute resistance load exercises
One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
干预措施: Acute resistant load exercises (Other)
Three acute resistance load exercises
One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
干预措施: Background Questionnaire (Behavioral)
Three acute resistance load exercises
One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
干预措施: Pain Questionnaire (Other)
Three acute resistance load exercises
One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
干预措施: DNA and RNA test (Genetic)
Three acute resistance load exercises
One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
干预措施: Ultrasound (Diagnostic Test)
Three acute resistance load exercises
One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
干预措施: Percutaneous Needle Core Biopsy (Diagnostic Test)
Control Group
One hundred volunteers will participate in study as a control group
干预措施: Background Questionnaire (Behavioral)
Control Group
One hundred volunteers will participate in study as a control group
干预措施: Pain Questionnaire (Other)
Control Group
One hundred volunteers will participate in study as a control group
干预措施: DNA and RNA test (Genetic)
Control Group
One hundred volunteers will participate in study as a control group
干预措施: Ultrasound (Diagnostic Test)
Control Group
One hundred volunteers will participate in study as a control group
干预措施: Percutaneous Needle Core Biopsy (Diagnostic Test)
结局指标
主要结局
Ultrasound Changes in Knee Muscle and Tendon
时间窗: One year
Comparison of results of pre- and post ultrasound changes after interventions between the 3 groups
Biopsy Changes in Knee Muscle and Tendon
时间窗: One year
Comparison of changes in biopsies taken before and after interventions between the 3 groups
Genetic Changes in Knee Muscle and Tendon
时间窗: One year
Comparison of results of genetic testing both before and after interventions between the 3 groups
次要结局
未报告次要终点