Comparative Resistance Exercise Effect on Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months
研究概览
简要总结
The purpose of this study is to determine if a 4 month resistance exercise program can reduce knee osteoarthritis pain functional impairment and cartilage turnover.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Osteoarthritis (OA) of the knee for >6 months
- •moderate to severe pain immediately following a 50-foot walk
- •knee pain primarily due to tibiofemoral OA and not from patellofemoral OA
- •bilateral standing anterior-posterior radiograph demonstrating grade 2 or 3 OA of the target knee
- •willing and able to participate in regular exercise for four months
- •free from musculoskeletal limitations that would preclude resistance exercise participation
- •free of abnormal cardiovascular responses during the screening graded maximal walk test
排除标准
- •unable to walk
- •regular resistance exercise training (>3X week) within the past 6 months
- •specific low back pain or acute back injury
- •spinal stenosis that precludes walking one block due to neurogenic claudication
- •any major injury to either knee within the prior 12 months
- •any surgery to either knee within the last 12 months
- •lumbar radiculopathy
- •vascular claudication
- •significant anterior knee pain due to diagnosed isolated patella-femoral syndrome or chondromalacia in either knee
- •have had corticosteroid or viscosupplement injections within three months of study participation
- •have added new over the counter or prescription pain medication within two months of study participation
研究组 & 干预措施
Wait-list Non-exercise Control (CON)
Subjects will continue to participate in their normal activities and clinical care during the four month study period if assigned to this group.
干预措施: normal activities and clinical care (Other)
Concentric Focused RX (CRX)
Training protocol for 1 set of each exercise will be completed - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.
干预措施: Concentric Focused Resistance Exercise (Other)
Eccentric Focused RX (ERX)
The Human Dynamics Laboratory features prototype equipment that increases resistance loads during the eccentric phase of the contraction while "assistance" is provided by the machine during the concentric phase. One set of each exercise - leg press, leg curl, leg extension, chest press, seated row, overhead press, triceps dip, biceps curl, and calf press.
干预措施: Eccentric Focused Resistance Exercise (Other)
结局指标
主要结局
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months
时间窗: Baseline, 4 Months
The WOMAC is a standard, multidimensional, self-administered functional-health status instrument for patients with lower limb OA. Subjects will complete the self-assessment at the time intervals indicated to document any change in their perception of their functional health status. Scale for Total score: the higher score means the worst the function and pain Total WOMAC scores will have a range of 0 to 96 (best and worst scores possible). 0-20 Womac pain (0= best, 20=worst) 0-8 Womac stiffness (0= best, 8=worst) 0-68 Womac functional (0= best, 68=worst) 0-96 Womac Total (0= best, 96=worst)
次要结局
- Chest Press; Change From Baseline at 4 Months(Baseline, 4 Months)
- Six Minute Walk Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Chair Rise Time and Stair Climb Time; Change From Baseline at 4 Months(Baseline, 4 Months)
- Leg Press Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Leg Extensions Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Leg Curl Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Shoulder Press Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Seated Row Test; Change From Baseline at 4 Months(Baseline, 4 Months)