Human Neck Brown Adipose Tissue mRNA Profile, a Seasonal Variation Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- Differences in gene expression in BAT associated genes (PGC1a, UCP1, CIDEA, PRDM16)
研究概览
简要总结
The primary objective in this study is to examine the seasonal variation in genetic markers in the deep neck adipose tissue in humans.
Human adipose tissue biopsies are taken from patients admitted for elective surgery in the neck. During the surgical procedure a subcutaneous adipose tissue biopsy is taken for reference.
详细描述
The knowledge of brown adipose tissue (BAT) is derived mainly from studies in rodents where cold is an important regulator of BAT development and function. Yet, little is known about the regulation of BAT in humans.
With this study the investigators aim to investigate the effects of seasonal changes in outdoor temperature on genetic markers of BAT in human deep neck adipose tissue.
Project participants are patients who are admitted to Aarhus University Hospital for elective neck surgery. Operations are primarily due to suspected malignancy in the thyroid gland or hyperparathyroidism.No additional surgery is necessary to obtain the biopsies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •written concent
排除标准
- 未提供
结局指标
主要结局
Differences in gene expression in BAT associated genes (PGC1a, UCP1, CIDEA, PRDM16)
时间窗: 1 day (The biopsies will be taken as a "point in time" value. Differences between seasons will be assesed. And so will correlations between genes at one point in time.)
biopsies will be grouped depending on outdoor temperature, differences in subcutaneous- and deep neck values,
次要结局
未报告次要终点
研究者
Peter Breining
MD PhD student
Aarhus University Hospital