Examination of the Effectiveness of Diffusion Weighted Magnetic Resonance Imaging for Identifying Poor Prognosis in Patients With Rheumatoid Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 1
研究概览
简要总结
Diffusion Weighted Imaging (DWI) MRI will assist in differentiating poor prognosis bone oedema more effectively than traditional T2 weighted MRI in patients with early Rheumatoid Arthritis (RA).
详细描述
Assess DWI MRI in patients with early Rheumatoid Arthritis to determine whether the MRI method will assist in differentiating poor prognosis bone oedema more effectively than traditional T2 weighted MRI.
Aim 1: To compare DWI MRI with T2 weighted MRI for the discrimination of different types of bone oedema lesions in patients with early RA.
Aim 2: To examine the association between the presence of different types of bone oedema lesions detected on DWI MRI and T2 weighted MRI and the development of subsequent joint bone erosion as detected on i) MRI and ii) standard plain radiographs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject has Rheumatoid Arthritis as defined by the ACR/Eular criteria
- •Subject is able to understand and comply with study protocol
- •Active disease as defined by DAS28> 3.0
- •Disease duration less than 12 months
- •If female, subject is either not of childbearing potential, or is of childbearing potential and is practicing an approved method of birth control throughout the study
- •subject is judged to be in good health as determined by the PI based upon results of medical history, laboratory profile and physical examination.
- •Prednisone dose 10mg or less, dose stable for 28 days prior to baseline
排除标准
- •Inflammatory arthropathy other than Rheumatoid Arthritis
- •Inactive disease as evidenced by DAS 28 CRP and / or ESR < 2.5
- •Prednisone dose greater than 10mg within 28 days prior to baseline
- •Intra-articular steroid within 28 days prior to baseline visit
- •IV Methyl-prednisone within 28 days prior to baseline visit
- •Any contra-indication to Magnetic Resonance Imaging
- •Permanent Pacemaker
- •Intracerebral aneurysm clip
- •Claustrophobia to the extent that patient cannot manage MRI investigations
- •Implanted metallic device
- •Cochlear implant
研究者
Paul Bird
Principal Investigator
Optimus Clinical Research