Optimization of Interval-training in Patients With Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Glycemic control
研究概览
简要总结
A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The time spend with high-intensity (fast) walking is considered to be responsible for the improvements seen, whereas the time spend with low-intensity (slow) walking is considered less important.
This study will assess if IW with maintained fast walking time duration but reduced total time duration (i.e. reduced slow walking time duration) is equally effective as IW with a normal time duration.
Subjects with type 2 diabetes will be included in a crossover, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:
- Sixty minutes of rest (CON)
- Sixty minutes of classical interval walking (repeated cycles of 3 minutes of fast and 3 minutes of slow walking; IW-60)
- Fourty-five minutes of time-reduced interval walking (repeated cycles of 3 minutes of fast and 1.5 minutes of slow walking; IW-45).
After the interventions subjects will undergo a standardized mixed meal tolerance test with assessment of glycemic control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 Diabetes Mellitus
- •BMI > 25
排除标准
- •Pregnancy
- •Contraindication to increased levels of physical activity
- •Eating disorder
- •Insulin dependence
研究组 & 干预措施
Control (CON)
No exercise intervention.
干预措施: CON (Behavioral)
Normal Interval Walking (IW-60).
Sixty minutes with repeated cycles of 3 minutes of fast and 3 minutes of slow walking on a treadmill
干预措施: IW-60 (Behavioral)
Time-reduced Interval Walking (IW-45)
Forty-five minutes with repeated cycles of 3 minutes of fast and 1.5 minutes of slow walking on a treadmill
干预措施: IW-45 (Behavioral)
结局指标
主要结局
Glycemic control
时间窗: Within the first 4 hours after the intervention
Glycemic control will be assessed after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test.
次要结局
- Stumvoll insulin sensitivity index(Within the first 4 hours after the intervention)
- Cederholm insulin sensitivity index(Within the first 4 hours after the intervention)
- Matsuda insulin sensitivity index(Within the first 4 hours after the intervention)
- HOMA-2 insulin resistance index(Within the first 4 hours after the intervention)
研究者
Anders Rasmussen Rinnov
MD, PhD
Rigshospitalet, Denmark