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临床试验/NCT02632318
NCT02632318已完成4 期

Dawn Simulation as a Passive Countermeasure to Postural Hypotension in Healthy Older Adults

VA Palo Alto Health Care System2 个研究点 分布在 1 个国家目标入组 35 人开始时间: 2016年9月1日最近更新:
适应症

试验速览

阶段
4 期
状态
已完成
发起方
入组人数
35
试验地点
2
主要终点
Sympathovagal balance derived from blood pressure measurement

研究概览

简要总结

One of the most physiologically demanding things that older people do every day is to get up in the morning. After spending a night laying flat, where the blood distributes evenly across the body, when they stand in the morning (and the blood rushes to their feet), their cardiovascular system may not be able to compensate and maintain blood flow to the brain. This phenomenon is known as orthostatic or postural hypotension. The investigators have found in a group of young individuals that use of a dawn-simulation light that gradually wakes the brain is able to increase cardiovascular tone prior to arising. The goal of this experiment is to determine whether this dawn simulation light is able to increase cardiovascular tone in older adults such that they would have reduced or absent postural hypotension when they awaken in the morning. This would greatly reduce the risks of falls and their associated morbidities in older adults.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
55 Years 至 85 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • History of falls or dizziness at exit from bed in the morning (at least two incidents in the past year)
  • At least 20/200 corrected visual acuity
  • Stable health
  • Normal hearing

排除标准

  • Regular cigarette smoker
  • Alcohol abuse
  • Drug abuse

结局指标

主要结局

Sympathovagal balance derived from blood pressure measurement

时间窗: 30 minutes

measure of sympathovagal balance derived from blood pressure measurement at wake time

次要结局

未报告次要终点

研究者

发起方
VA Palo Alto Health Care System
申办方类型
Fed
责任方
Principal Investigator
主要研究者

Jamie M. Zeitzer, Ph.D.

Assistant Professor

VA Palo Alto Health Care System

研究点 (2)

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