Dawn Simulation as a Passive Countermeasure to Postural Hypotension in Healthy Older Adults
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Sympathovagal balance derived from blood pressure measurement
研究概览
简要总结
One of the most physiologically demanding things that older people do every day is to get up in the morning. After spending a night laying flat, where the blood distributes evenly across the body, when they stand in the morning (and the blood rushes to their feet), their cardiovascular system may not be able to compensate and maintain blood flow to the brain. This phenomenon is known as orthostatic or postural hypotension. The investigators have found in a group of young individuals that use of a dawn-simulation light that gradually wakes the brain is able to increase cardiovascular tone prior to arising. The goal of this experiment is to determine whether this dawn simulation light is able to increase cardiovascular tone in older adults such that they would have reduced or absent postural hypotension when they awaken in the morning. This would greatly reduce the risks of falls and their associated morbidities in older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 85 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •History of falls or dizziness at exit from bed in the morning (at least two incidents in the past year)
- •At least 20/200 corrected visual acuity
- •Stable health
- •Normal hearing
排除标准
- •Regular cigarette smoker
- •Alcohol abuse
- •Drug abuse
结局指标
主要结局
Sympathovagal balance derived from blood pressure measurement
时间窗: 30 minutes
measure of sympathovagal balance derived from blood pressure measurement at wake time
次要结局
未报告次要终点
研究者
Jamie M. Zeitzer, Ph.D.
Assistant Professor
VA Palo Alto Health Care System
