NL-OMON52326招募中不适用
Glucose transport and mitochondrial function in type 1 diabetes mellitus - GRACE
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 41
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •In order to be eligible to participate in this study, participants with T1DM
- •must meet all of the following criteria:
- •Individuals with T1DM with a diagnosed disease duration of 1 - 45 years
- •Male or female
- •Aged between 18-65 years
- •In order to be eligible to participate in this study, healthy control
- •participants must meet all of the following criteria:
- •No chronic health conditions and between the ages of 18-65
排除标准
- •History of asthma, stroke, chronic obstructive pulmonary disease, congestive
- •heart failure, heart surgery, or congenital heart diseases
- •Current treatment with drugs known to interfere with metabolism e.g. systemic
- •corticosteroids, statins, SGLT2 inhibitors, GLP1 receptor agonists
- •Are current smokers or have been a regular smoker within the last 12 months
- •Insulin pump therapy
- •Symptomatic autonomic or distal neuropathy
- •BMI >30 due to adiposity, since this is known to cause difficulties in
- •obtaining muscle biopsies.
- •Pregnancy
- •Recent acute myocardial infarction (<6 months)
- •Uncontrolled arrhythmia/severe conduction disorder (atrial fibrillation or
- •second/third degree AV block) causing hemodynamic compromise
- •Implantable pacemaker or other cardiac device with complete ventricular pacing
- •Uncontrolled heart failure with hemodynamic compromise
- •Uncontrolled hypertension (Systolic Blood Pressure >150 mmHg and Diastolic
- •Blood Pressure > 100 mmHg on repeated measurements)
- •Active infection, anaemia, severe renal dysfunction (estimated Glomerular
- •filtration rate <30 ml/min/1,73m2) likely to significantly impact on exercise
- •performance
- •Chronic illness (including orthopaedic, endocrinological, haematological,
- •malignant, gastrointestinal, neurological, muscle or inflammatory disorders)
- •likely to significantly impact on exercise performance
- •> 6 alcohol units per day or >14 alcohol units per week
- •Use of anticoagulants or anti platelet therapy
研究者
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