Comparison of Thromboelastography-derived Functional Fibrinogen Levels During and After Cardiopulmonary Bypass
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Change in Thromboelastography-derived Functional Fibrinogen Level (FLEV)
研究概览
简要总结
This study hopes to determine if thromboelastography-derived functional fibrinogen (TEG-FF or FLEV) levels obtained during the rewarming phase of cardiopulmonary bypass can provide information on coagulation status sooner, allowing for anticipation of post-bypass bleeding and transfusion requirements
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective cardiac surgery patients who are undergoing primary cardiac surgery
排除标准
- •Emergency surgery
- •Re-operative cardiac surgery
- •History of hypercoagulable state as defined in medical record
- •Anticoagulated status at time of surgery
- •Plasma requirement prior to discontinuation of bypass (alters fibrinogen level)
结局指标
主要结局
Change in Thromboelastography-derived Functional Fibrinogen Level (FLEV)
时间窗: Change in FLEV from rewarming and after cardiopulmonary bypass
FLEV values obtained during rewarming while on cardiopulmonary bypass (CPB) were compared to FLEV values obtained immediately after CPB and protamine administration. For all patients included, the mean values for rewarming FLEV and mean values for post-CPB FLEV were obtained. If the mean difference for the two timepoints was not statistically different by t-test, then the primary outcome would demonstrate the value of obtaining a rewarming FLEV sample.
次要结局
- Difference in Clauss Assay and FLEV(Clauss vs FLEV for rewarming and post-CPB)