NCT04542863招募中不适用
The Molecular Imaging Research of F-18 Labeled DX600 PET Probe
Peking University Cancer Hospital & Institute1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2020年9月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Standard uptake value (SUV)
研究概览
简要总结
Angiotensin-converting enzyme 2 (ACE2) plays an important role in renin-angiotensin system (RAS) and has been reported to relate with cancer. Recently, it has also been proved as the key target for COVID-19 infection.
DX600 is a polypeptide that can specific binding to ACE2 specifically with nanomolar affinity reported in literature. This study constrcuted a radio-tracer, DX600 Labeled by PET Radionuclide, to monitoring biodistribution ACE2 in human beings, evaluate the detection ability of radio-tracer in ACE2 over-expression tumors and dynamic changes of ACE2 expression under therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age >3 years old; both sex;
- •ECoG 0 or 1;
- •Patients that would undergo biopsy or surgical operation with high ACE2 expression tumors such as colorectal cancer, renal cancer, pancreatic cancer, gastric cancer, liver cancer, lung cancer, brain cancer or suspected tumor.
- •use 18F-FDG PET/CT as baseline evaluation
排除标准
- •Significant hepatic or renal dysfunction;
- •Is Pregnant or ready to pregnant;
- •Cannot lie on their back for half an hour;
- •Suffering from claustrophobia or other mental diseases;
- •Refusal to join the clinical study;
结局指标
主要结局
Standard uptake value (SUV)
时间窗: 2 years
次要结局
未报告次要终点
研究者
Hua Zhu
Associate Professor
Peking University Cancer Hospital & Institute
研究点 (1)
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