Primary Aldosteronism In Hypertensive Patients in China
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3,500
- 试验地点
- 1
- 主要终点
- Number of subjects with newly diagnosed hypertension
研究概览
简要总结
To investigate the prevalence of primary aldosteronism (PA) in Chinese patients with newly diagnosed hypertension.
详细描述
This is a nationwide sampling study. To investigate the prevalence of primary aldosteronism (PA) in Chinese patients with hypertension, we will conduct a case detection of PA in Chinese hypertensive patients from 10 centers of China (including Beijing, Chongqing, Shanghai, Guangzhou, et al.); furthermore, a case confirmation of PA (captopril challenge test and saline infusion test) will be performed if the result of case detection is positive. This study will be completed in two years.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newly diagnosed hypertension(with a course less than six months);
- •Drug negative, or voluntary to discontinue/change the anti-hypertensive medications;
- •Aged between 18-80 year, gender is not limited;
- •Voluntary to sign on the informed consent.
排除标准
- •patients with severe cardiac, hepatic or renal dysfunction;
- •suspicious or confirmed other types of secondary hypertension, including Cushing's syndrome, pheochromocytoma and renal artery stenosis.
结局指标
主要结局
Number of subjects with newly diagnosed hypertension
时间窗: 2 years
To calculate the prevalence of PA in Chinese patients with hypertension
Number of subjects with confirmed primary aldosteronism (PA)
时间窗: 2 years
To calculate the prevalence of PA in Chinese patients with hypertension
Prevalence of PA
时间窗: 2 years
Prevalence of PA= Number of PA / Number of subjects with hypertension
次要结局
- Cardiovascular events(2 years)
- Blood pressure(2 years)
- Fasting blood glucose(2 years)
- Age(2 years)
- Family history of hypertension(2 years)
研究者
Qifu Li
Primary Investigator
Chongqing Medical University