NCT03035344Unknown不适用
Study of the Intermediate Metabolism in Children With Acute Lymphoblastic Leukemia
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Difference in measurement of aminoacids and organic acids between ALL patients and healthy matched controls.
研究概览
简要总结
Study of the intermediate metabolism in children diagnosed with ALL compared to healthy matched controls.
详细描述
The primary cause of this study is to investigate the changes that ALL may cause to the metabolome of pediatric patients, in order to better understand its mechanism of action and target metabolic pathways for potential therapies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Children with a known chronic illness before ALL diagnosis 2) ALL remission 3) Not signed informed consent
- •Population description: Patients are recruited from the Pediatric Hematology/Oncology Department of Aristotle University of Thessaloniki (AHEPA hospital) and from the Pediatric Hematology/ Oncology Department of Ippokration Hospital, that host all children diagnosed with ALL in nothern Greece. Matched controls are recruited from outpatient clinic of the 2nd and 4th Pediatric Department of Aristotle University of Thessaloniki.
- •Sampling method: Non-probability sample
结局指标
主要结局
Difference in measurement of aminoacids and organic acids between ALL patients and healthy matched controls.
时间窗: Up to six months
The title of aminoacids in blood and urine and of organic acids in urine will be measured through Tandem Mass Spectrometry
次要结局
未报告次要终点
研究者
Maria T. Papadopoulou
Principal investigator, MD, PhD candidate
Aristotle University Of Thessaloniki
研究点 (1)
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