RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Behavioral performance during scene categorization tasks
研究概览
简要总结
The RePer-AGE study investigates how central and peripheral vision contribute to visual recognition and how these mechanisms change with normal aging. The study is based on the hypothesis that peripheral vision provides rapid global information that supports visual recognition through predictive mechanisms. Healthy young adults (18-30 years) and older adults (60-85 years) will undergo visual psychophysical testing, ophthalmological examinations, and, for a subset of participants, functional magnetic resonance imaging (fMRI). The results are expected to improve our understanding of age-related changes in visuo-cognitive functions and provide reference data for future studies on age-related visual disorders.
详细描述
Visual recognition depends on the complementary contribution of central and peripheral vision. Central vision provides high spatial resolution and supports the detailed analysis required for object identification, whereas peripheral vision rapidly extracts coarse visual information that provides a global representation of the surrounding environment. According to predictive models of visual processing, this early peripheral information is used to generate predictions that facilitate the subsequent processing of detailed visual inputs.
The RePer-AGE project is based on the hypothesis that peripheral vision plays a key role in predictive visual processing and that this contribution changes during normal aging. Although aging is associated with well-documented declines in visual acuity and contrast sensitivity, particularly for high spatial frequencies, several findings suggest that the processing of coarse visual information conveyed by peripheral vision may be relatively preserved. This preserved processing may contribute to compensatory mechanisms supporting visual recognition in older adults.
RePer-AGE is a prospective, monocentric interventional study conducted at Grenoble Alpes University Hospital (CHU Grenoble Alpes) and the Laboratoire de Psychologie et NeuroCognition (LPNC, CNRS, Université Grenoble Alpes). The study will recruit 160 healthy volunteers divided into two age groups: young adults (18-30 years) and older adults (60-85 years). Participants will undergo an ophthalmological examination to ensure normal or corrected-to-normal vision and the absence of ocular disease likely to affect visual performance. Older participants will also complete a brief cognitive screening assessment.
The project combines complementary behavioral, ophthalmological, and neuroimaging approaches to investigate the respective contributions of central and peripheral vision to visual recognition.
The first research axis combines psychophysical experiments with ophthalmological assessments. Participants perform computerized visual recognition tasks specifically designed to evaluate the relative contribution of central and peripheral vision. Additional ophthalmological examinations include automated static perimetry to assess retinal sensitivity across the visual field and low-luminance visual acuity testing. These measurements will allow the relationship between retinal function and visual recognition performance to be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy young adults aged 18 to 30 years or healthy older adults aged 60 to 85 years.
- •Normal or corrected-to-normal visual acuity.
- •No ophthalmological disease affecting visual function.
- •For participants aged 60 years or older: Mini-Mental State Examination (MMSE) score ≥
- •Affiliated with a national health insurance system.
- •Written informed consent.
- •Non inclusion Criteria:
- •Individuals protected under French regulations governing research involving human participants.
- •Employees or individuals under the direct authority of the investigators.
- •History of neurological or psychiatric disorders likely to affect visual or cognitive functions.
- •Current treatment likely to alter visual function or vigilance.
- •MRI contraindications (metallic implants, pacemaker, severe claustrophobia, or other MRI safety contraindications) for participation in the MRI arm only.
排除标准
- 未提供
结局指标
主要结局
Behavioral performance during scene categorization tasks
时间窗: Baseline (single experimental session)
Behavioral performance will be assessed using accuracy and response time during computerized scene categorization tasks evaluating (1) central versus peripheral vision (EXC paradigm) and (2) semantic congruency between peripheral and central vision (VPC paradigm). Comparisons will be performed between young and older adults.
次要结局
- Retinal sensitivity(Baseline)
- Brain activation during visual recognition(Baseline)