A randomised trial of a Lung-Open Ventilation Strategy in acute lung injury

McMaster University (Canada)0 个研究点目标入组 980 人开始时间: 2005年8月11日最近更新: 2015年1月13日

试验速览

暂无简介。

•Persons of either sex 18 years and older.
•1. Invasive mechanical ventilation
•2. Acute respiratory insufficiency (within past 28 days)
•3. Bilateral infiltrates on frontal chest radiograph
•4. Hypoxemia, defined as paO2/FiO2 less than or equal to 250, on any amount of Positive End-Expiratory Pressure (PEEP)

•1. Primary cause of respiratory failure is cardiac
•2. Anticipated duration of mechanical ventilation <48 hours, as judged by the intensivist
•3. Inability to wean from other experimental ventilation strategies
•4. Severe chronic respiratory disease
•5. Neuromuscular disease that will result in prolonged need for mechanical ventilation
•6. Conditions where hypercapnia-induced intracranial hypertension should be avoided
•7. Morbid obesity (>1 kg per cm body weight)
•8. Pregnancy
•9. Very unlikely to survive in the judgment of the investigator, and luck of commitment to life support
•10. Malignancy or underlying irreversible condition with 6 month mortality greater than or equal to 50%
•11. Greater than 48 hours elapsed since first eligible in study hospital
•12. Current participation in competing trial
•13. Lack of physician, patient or proxy consent

发起方

McMaster University (Canada)