Evaluation of lung lavage in meconium aspiration syndrome

Phase 3

Completed

• Conditions: Meconium aspiration syndrome; Reproductive Health and Childbirth - Complications of newborn; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12606000290594
• Lead Sponsor: A/Prof Peter Dargaville

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2004-10-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

Neonates (males and females)with confirmed diagnosis of meconium aspiration syndrome with all of the following:1. birth weight >2.0kgs, gestation >36 weeks.2. <24 hours of age3. ventilated with mean airway pressure >/= 12 cm H2O4. Alveolar-arterial oxygen difference >/= 450 mmHg

Exclusion Criteria

Known or suspected cardiac abnormality. Severe hypoxic ischaemic encephalopathy or congenital anomaly (ie, withdrawal of treatment being considered). Intractable cardiorespiratory instability.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total duration of respiratory support (ventilation plus nasal continuous positive airway pressure) during initial hospitalisation[First hospitalisation]

Secondary Outcome Measures

Name	Time	Method
Mortality[First hospitalisation];Incidence of pneumothorax[First hospitalisation];Duration of oxygen therapy[First hospitalisation];Intubation and hospitalisation[First hospitalisation];Respiratory morbidity[In 1st year pf life.];Neurodevelopmental outcome[At 2 years.]