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临床试验/NCT05584995
NCT05584995已完成不适用

Uterine Artery Color Doppler Parameters After Bilateral Uterine Artery Ligation for Postpartum Hemorrhage

Tanta University1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2020年8月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
70
试验地点
1
主要终点
Color Doppler parameters

研究概览

简要总结

The aim of this study is to assess Uterine artery color doppler parameters after bilateral uterine artery ligation (BUAL) for Postpartum Hemorrhage.

详细描述

Obstetric haemorrhage is the main reason of maternal death in both countries with high and poor incomes. Most of these deaths occurred within the first 24 hours following birth. Placenta accrete, retained placenta, genital tract lacerations, uterine rupture, and coagulation abnormalities are established risk factors for postpartum hemorrhage. The management of Idiopathic pulmonary hemosiderosis (IPH) and postpartum hemorrhage relies on numerous considerations: type of delivery (vaginal or caesarean delivery), bleeding etiology (uterine atony, trauma, retained placenta) and hemodynamic stability.

In the first stage, early identification, and treatment with uterotonics, suturing the lacerations, and fundal massage are crucial. When bleeding persist, even in the aggressive medical treatment, suitable surgical intervention should be performed.

Surgical therapy relies on the patient's desire to maintain fertility, the severity of the bleeding, and the surgeon's experience.

Historically, peripartum hysterectomy was the only available management to prevent postpartum hemorrhage but, in some instances, hysterectomy alone is insufficient to control the bleeding.

Also, the desire to preserve fertility have resulted in the development of other techniques, such as pelvic embolization and internal iliac artery ligation (IIAL)and bilateral uterine artery ligation (BUAL).

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

年龄范围
20 Years 至 35 Years(Adult)
性别
Female
接受健康志愿者
否

入选标准

  • •70 women aged between 20 and 35 years old.
  • •Undergoing Bilateral Uterine Artery Ligation after Postpartum Hemorrhageafter cesarean section
  • •resistant to medical treatment, and did not need to hysterectomy.

排除标准

  • •Patients with male factor, tubal factor, and absence of lactation.
  • •Diabetes mellitus, hypertension, morbid obesity, autoimmune disease, or vascular disease in the history, smoking.
  • •Intrauterine growth restriction in previous pregnancies history, detection of a uterine anomaly or a medical condition, as well as administration of a hormonal treatment during the study.
  • •Uncontrolled bleeding is needed for a hysterectomy.

研究组 & 干预措施

Control group

Experimental

Women will undergo normal cesarean section without Postpartum Hemorrhage or Idiopathic pulmonary hemosiderosis (IPH)

干预措施: Control group (Procedure)

BUAL group

Experimental

Cases will undergo Bilateral Uterine Artery Ligationafter Postpartum Hemorrhage after cesarean section resistant to medical treatment and did not need a hysterectomy.

干预措施: BUAL group (Procedure)

结局指标

主要结局

Color Doppler parameters

时间窗: After Bilateral Uterine Artery Ligation

Color Doppler parameters for measuring the UtA diameters as UtA pulsatility Index will be recorded

次要结局

  • The uterine artery's descending branches(After Bilateral Uterine Artery Ligation)
  • The uterine artery's ascending branch(After Bilateral Uterine Artery Ligation)
  • Color Doppler parameters(After Bilateral Uterine Artery Ligation)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Ossman

Assistant professor

Tanta University

研究点 (1)

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