The effect of locally administered platelet-rich plasma injection on the acceleration of orthodontic tooth movement: A Split mouth study

Orthodontic treatment, aimed at correcting malocclusions and enhancing dental aesthetics, typically involves a prolonged duration due to the natural constraints of bone architecture. One of the main deterrents for patients to decline orthodontic treatments is the inconvenience of having long-term procedures. The canine retraction is one such common procedure that might take up to seven to eight months for its completion. So the concept of accelerating orthodontic tooth movement (OTM) has garnered significant interest among orthodontists and researchers alike, seeking to reduce treatment duration and enhance the patient experience. Over time, several methods have been developed to shorten the course of treatment.

Microimpulses, low-dose laser therapy, and pharmaceuticals are examples of such noninvasive techniques. Surgically assisted methods including corticision, micro-osteoperforation, piezocision, periodontal ligament distraction, and periodontally accelerated osteogenic orthodontics are examples of invasive treatments. Research has demonstrated that invasive procedures harm the alveolar bone. The mechanical simulation brought on by invasive procedures increases osteoclastic activity, which in turn causes the alveolar bone to resorb, reducing its density and causing the targeted teeth’s bone to disappear.

Platelet-rich plasma (PRP) is currently utilized across numerous medical specialties and has been viewed as an orthobiological adjuvant therapy in recent times. Because PRP is being used for a variety of purposes in dermatology, including tissue regeneration, wound healing, scar revision, skin rejuvenating benefits, and alopecia, interest in its usage has recently exploded. PRP has the ability and potential to encourage periodontal regeneration via a variety of methods. The concentration of PRP employed determines its impact on the localized acceleration of tooth movement. Nonetheless, the effectiveness of PRP-based tooth movement acceleration depends on the synthesis method. Injectable PRP can influence bone quality and accelerate tooth movement, therefore using it at a different stage of orthodontic therapy can improve the quality of the outcome.

This study aims to investigate the effect of locally administered PRP injections on accelerating orthodontic tooth movement through a split-mouth study design. By administering PRP on the Experimental side of the oral cavity while using conventional orthodontic mechanics on the control side, the study seeks to isolate and evaluate the specific impact of PRP on the rate of tooth movement.

Understanding the underlying mechanisms through which PRP influences orthodontic tooth movement is crucial for optimizing treatment protocols and enhancing clinical outcomes. This study will not only contribute to the growing body of evidence in the field of orthodontics but also holds the potential to revolutionize orthodontic practice by offering a safe and effective means of expediting treatment duration while ensuring optimal patient outcomes.

This study will explore the complex relationship between PRP injection and orthodontic tooth movement to offer insightful information that can guide evidence-based clinical practice and open the door to more developments in orthodontic therapy.