Exploratory Analysis on the Impact of Morbidities on Colorectal Cancer Screening Uptake
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8,776
- 试验地点
- 1
- 主要终点
- Individual attended colorectal cancer screening
研究概览
简要总结
The primary aim of this project is to examine the association between having a long-term condition (morbidity) and screening uptake for colorectal cancer. Whilst this project will consider all morbidity and co-morbidities, there will be a particular focus on common mental health disorders, such as depression and anxiety.
The secondary aim of this project is to examine other factors that may influence uptake rate. Information on a wide array of potential factors is available for this project. These include demographics (age, gender, ethnicity), socio-economic status (deprivation, education status) and lifestyle (smoking status, drinking patterns, degree of exercise). In addition, any potential moderating effect of these factors on the association between morbidity and screening uptake shall be explored.
In summary, the following shall be explored:
- Uptake rates by type of mental health disorder.
- Uptake rates by chronic physical health problems.
- Associations between uptake, morbidity (both physical and mental) and broader health determinants such as demographics, socio-economic status and lifestyle.
详细描述
Linkage of datasets and ethical issues.
The South Yorkshire Cohort (SYC) data (including patient identifiers) are held by the Clinical Trials Research Unit (CTRU) at the University of Sheffield, whilst Bowel Cancer Screening Programme (BCSP) data are held by the NHS Cancer Screening Programmes (part of Public Health England).
Linkage will be based on the subset of respondents to the SYC who have given their consent for the SYC researchers to look at their NHS health records, and are eligible to be invited for colorectal cancer (CRC) screening. The proposed method for linkage will be as follows:
- For those respondents who have given this consent, the CTRU shall send their NHS number and their SYC study ID to the BCSP.
- Using the NHS number, the BCSP shall extract data on if the individual was invited for screening, and if so whether or not the individual accepted screening.
- The BCSP shall then send the screening data along with the SYC study ID to the CTRU. NHS number shall not be included in the data that is sent from the BCSP (in other words it will be pseudo-anonymised).
- The CTRU shall use the pseudo-ID to link the screening programme data to the SYC data. A pseudo-anonymised dataset shall then be released to the research team.
In this way, the only patient-identifiable data that the BCSP would receive is data that they already hold (NHS number), whilst the CTRU would not receive any additional patient-identifiable data.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 60 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants in the South Yorkshire Cohort
- •Eligible for screening in the NHS Bowel Cancer Screening Programme.
排除标准
- •Have not ticked both boxes on the Consent Form (part of the South Yorkshire Cohort questionnaire) for their data to be used
结局指标
主要结局
Individual attended colorectal cancer screening
时间窗: The duration for which the individual was eligible for screening (between 1 and 10 years)
If the individual attended any colorectal cancer screen (irrespective of the number of invitations) - analysed as a binary yes/no indicator per individual using logistic regression.
次要结局
- Individual accepted colorectal cancer screening after refusing the initial invitation for colorectal cancer screening(The duration for which the individual was eligible for screening (between 1 and 10 years))
研究者
Ben Kearns
Research Associate
University of Sheffield