Comparison of the effectiveness of endotracheal instillation of lignocaine versus normal saline in prevention of cough during extubation after elective laparoscopic surgeries : A randomized control study

A typical clinical issue, coughing upon coming out of general anaesthesia can cause potentially harmful patient movements, hypertension, tachycardia or other arrhythmias, myocardial ischaemia, surgical haemorrhage, bronchospasm, and a rise in intracranial and intraocular pressure.

In individuals with coronary artery disease, cerebrovascular disease, or intracranial hypertension, coughing during extubation may have harmful implications.

Lidocaine is a local anaesthetic which has long been used to obtund intubation response. According to studies, stimulation of the larynx, trachea, and carina all result in haemodynamic abnormalities that lidocaine prevents. The larynx is the one that causes the greatest reaction among them.Endotracheal instillation of Lidocaine in the cuff in order to inflate the cuff prevents coughing and thereby prevents an increase in blood pressure and heart rate throughout the surgery. But repeated instillation may be required as it may get absorbed through the cuff. Endotracheal instillation of Lidocaine has been shown to obtund intubation response. Similar instillation through the endotracheal tube to obtund the response to extubation is sparsely studied.

The aim of the study is to investigate whether endotracheal instillation of lignocaine attenuates cough and airway circulatory reflex during extubation after elective laparoscopic surgeries requiring general anaesthesia.