Artificial Oocyte Activation Comparing Tow Different Agents
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 450
- 试验地点
- 3
- 主要终点
- Pregnancy rate ( % )
研究概览
简要总结
Comparing the efficacy of tow factors for artificial Oocyte Activation for poor quality Oocytes and Teratozoospermia patients.
详细描述
The IVF outcome had been varied widely with a good portion of total fertilization failure even after the most advanced procedure for this group of patient Intracytoplasmic Sperm Injection, many factors that had been tested for assisting the failed group of patient to be fertilized artificially like Ca Ionophore, Strontium Chloride and others but we decide to compare the clinically proven factors for the efficacy and safety in a well randomized clinical trial and monitor the embryogenesis and pregnancy within the 2 groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •previous fertilization failure
- •poor quality Oocytes
- •poor sperms
排除标准
- •normal patients
研究组 & 干预措施
Ca Ionophore group
Artificial Oocyte activation with Ca Ionophore for 20 min after Intracytoplasmic Sperm Injection
干预措施: Ca Ionophore (Drug)
Ca Ionophore group
Artificial Oocyte activation with Ca Ionophore for 20 min after Intracytoplasmic Sperm Injection
干预措施: Artificial Oocyte activation (Other)
Strontium Chloride group
Artificial Oocyte activation with Strontium Chloride for 60 min after Intracytoplasmic Sperm Injection
干预措施: Artificial Oocyte activation (Other)
Strontium Chloride group
Artificial Oocyte activation with Strontium Chloride for 60 min after Intracytoplasmic Sperm Injection
干预措施: Strontium Chloride (Drug)
结局指标
主要结局
Pregnancy rate ( % )
时间窗: 9 months
次要结局
- Blastocyst rate ( % )(9 months)
研究者
Muhammad Fawzy
IVF Lab Director
Ibn Sina Hospital