NCT07569315尚未招募2 期
Successive Doses of GnRH Agonist Versus Single Dose of GnRH Agonist to Trigger Ovulation in Hyper-responders Undergoing IVF Cycle : A Randomized Controlled Study.
Bedaya Hospital1 个研究点 分布在 1 个国家目标入组 190 人开始时间: 2026年6月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 190
- 试验地点
- 1
- 主要终点
- Metaphase-II oocytes rate
研究概览
简要总结
The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered 36 hours before oocyte retrieval ) in triggering ovulation in hyper-responders
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •GnRH antagonist IVF cycle
- •Hyper-responders to induction of ovulation
排除标准
- •Hypogonadotrophic hypogonadism
- •Endometriosis
- •History of recurrent abortion
研究组 & 干预措施
Single dose GnRH agonist
Active Comparator
A single dose of GnRH agonist is administered 36 hours before oocyte retrieval
干预措施: Single dose GnRH agonist (Drug)
Successive doses GnRH agonist
Experimental
Three successive doses of GnRH agonist are administered 36 , 24 and 12 hours before oocyte retrieval
干预措施: Successive doses GnRH agonist (Drug)
结局指标
主要结局
Metaphase-II oocytes rate
时间窗: Ten to fifteen days after starting ovarian stimulation
Number of MII oocyte/ number of cumulus oocyte complex
次要结局
- Clinical pregnancy rate(Five weeks after embryo transfer)
- Ongoing pregnancy Rate(Eighteen weeks after embryo transfer)
研究者
研究点 (1)
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