NCT03370783已完成不适用
Acute Neuroimmune Effects of Alcohol Using Free Water Imaging
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Immune biomarkers
研究概览
简要总结
This study examines the effects of moderate alcohol intake on the brain, the immune system, and cognition.
详细描述
The study involves a within-subjects, pre/post design to assess the effects of a moderate dose of alcohol on immune biomarkers, neurobiological measures, and cognitive functioning. The study recruits healthy adults (ages 21-45) from the community to complete the experimental protocol. Participants complete magnetic resonance imaging scans, blood sample collection, and cognitive testing in the context of alcohol consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 21-45 years
- •Able to speak and read English at least at 8th grade level
- •Moderate self-reported alcohol use in the past year
- •Body mass index in normal to overweight range
- •Right-handed
排除标准
- •History of heavy drinking
- •Currently seeking alcohol or drug treatment
- •Chronic disease requiring use of medication
- •Recent antibiotic or probiotic use
- •Chronic daily use of NSAIDs
- •Chronic GI disorder
- •Use of illicit drugs
- •Major psychiatric disorder or suicidality
- •Fainting, weakness, infection, excessive bruising, or distress resulting from standard blood draw
- •Safety contraindication for MRI scan
- •Inability to abstain from use of tobacco products prior to or during study
- •Inability to abstain from use of cannabis prior to or during study
- •Pregnant, nursing, or may become pregnant
结局指标
主要结局
Immune biomarkers
时间窗: 1-3 hours after alcohol intake
次要结局
未报告次要终点
研究者
Mollie Monnig
Assistant Professor of Behavioral and Social Sciences
Brown University
研究点 (2)
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