Internal carotid artery blood flow response to anaesthesia, pneumoperitoneum and head up tilt during laparoscopic cholecystectomy: a clinical study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- To derive and study changes in internal carotid artery blood flow ultrasonographically in patients
研究概览
简要总结
This study is aimed studying blood flow changes in Internal Carotid Artery in patients undergoing laparoscopic cholecystectomy under general anaesthesia. Diameter and velocity of Internal carotid artery will be calculated using ultrasonography at following time points - before induction of anaesthesia, just after induction, after creation of pneumoperitoneum and after head up tilt, along with other vital parameters like blood pressure, heart rate, oxygen saturation and end tidal carbon dioxide. Significant physiological changes can occur during1. Induction of anaesthesia2. Creation of pneumoperitoneum 3. Head up tilt ( reverse Trendelenburg position ) the proposed study further add to our knowledge how the internal carotid artery blood flow and cardiac output is affected during different stages of laparoscopic cholecystectomy under general anaesthesia.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •consenting patients of either sex undergoing elective laparoscopic cholecystectomy under general anaesthesia.
- •Age 18-60 years
- •Non obese patients (BMI equal to or less than 32kg/m2)
- •Patients belonging to physical status ASA grade I/II.
排除标准
- •patients falling in criteria but not giving consent to participate in the study.
- •ASAngrade III/IV/V
- •patients with hyperlipidaemia, known coronary artery disease, hyertension, cerebrovascular disease, diabetes mellitus, patients on beta blockers or on statin therapy.
结局指标
主要结局
To derive and study changes in internal carotid artery blood flow ultrasonographically in patients
时间窗: 1- Awake - just before induction of anaesthesia. | 2- Two minutes after induction of anaesthesia, | 3- Two minutes after creation of pneumoperitoneum and | 4- Two minutes after providing head up tilt.
undergoing elective laparoscopic cholecystectomy under general anaesthesia in terms of internal
时间窗: 1- Awake - just before induction of anaesthesia. | 2- Two minutes after induction of anaesthesia, | 3- Two minutes after creation of pneumoperitoneum and | 4- Two minutes after providing head up tilt.
carotid artery diameter, internal carotid artery velocity and beat volume
时间窗: 1- Awake - just before induction of anaesthesia. | 2- Two minutes after induction of anaesthesia, | 3- Two minutes after creation of pneumoperitoneum and | 4- Two minutes after providing head up tilt.
次要结局
- To derive and calculate cardiac output by Liljestrand and Zander formula(1- Awake - just before induction of anaesthesia.)