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临床试验/NCT07761585
NCT07761585已完成不适用

Effect of Preoperative Dexamethasone in Preventing Spinal Hypotension In Patients Undergoing Elective Caesarian Section

Liaquat National Hospital & Medical College1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2026年2月1日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
已完成
入组人数
80
试验地点
1
主要终点
Spinal hypotension

研究概览

简要总结

The goal of this clinical trial is to learn whether giving a single dose of intravenous dexamethasone before spinal anesthesia can help prevent low blood pressure (spinal hypotension) in pregnant women undergoing elective cesarean section. Low blood pressure after spinal anesthesia is common and may cause nausea, vomiting, dizziness, and reduced blood flow to the baby. If dexamethasone works, it may help maintain stable blood pressure during surgery, reduce the need for medicines used to treat low blood pressure, and improve the safety and comfort of both the mother and baby.

The main questions it aims to answer are:

  • Does preoperative intravenous dexamethasone reduce the occurrence of spinal hypotension after spinal anesthesia?
  • Does dexamethasone reduce the amount of vasopressor medicine needed to treat low blood pressure during surgery?

Researchers will compare 8 mg intravenous dexamethasone with normal saline (placebo) to determine whether dexamethasone is more effective in preventing spinal hypotension during elective cesarean section.

Participants will:

  • Receive either intravenous dexamethasone or a placebo before spinal anesthesia.
  • Undergo elective cesarean section under spinal anesthesia.
  • Have their blood pressure monitored during surgery.
  • Receive standard treatment if their blood pressure becomes too low.
  • Have their blood pressure measurements and the need for blood pressure-raising medicines recorded to compare the effects of the two treatments.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Triple (Participant, Care Provider, Investigator)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • Pregnant females Consenting No contraindications

排除标准

  • Non consenting

研究组 & 干预措施

Dexamethasone

Active Comparator

干预措施: Dexamethasone (Drug)

Placebo

Placebo Comparator

干预措施: Dexamethasone (Drug)

结局指标

主要结局

Spinal hypotension

时间窗: From spinal anesthesia until delivery of the baby (approximately 20 minutes) at 5 minutes interval for a period of 6 months.

The incidence of spinal hypotension, defined as a decrease in systolic blood pressure (SBP) greater than 20% of the baseline value or an absolute SBP \<90 mmHg after spinal anesthesia, will be compared between the dexamethasone and placebo groups. Blood pressure will be measured every 5 minutes until delivery of the baby.

次要结局

  • Vasopressor Requirement(From spinal anesthesia until delivery of the baby (approximately 20 minutes ) at 5 minutes interval for a period of 6 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Maryam Khan

Resident

Liaquat National Hospital & Medical College

研究点 (1)

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