NCT00192803Unknown4 期
ACE/ACE2 Ratio in Diabetic Patients Treated With Antihypertensive Drugs
适应症
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- ACE and ACE2 activities in monocytes
研究概览
简要总结
This feasibility study is designed to examine modulation of the relative activities of ACE and ACE2 in diabetic patients following treatment with the angiotensin type 1 receptor (AT1R) antagonist, Candesartan.
This study will provide a closer insight to the possible involvement of the renin-angiotensin system (RAS)-related enzymatic components in development or attenuation of vascular pathogenesis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Ect
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed informed consent
- •Non-smokers
- •Type II DM diagnosed patients
- •Blood pressure < 135/90
- •Serum HbA1C > 7%
- •Serum creatinine < 1mg%
- •Urine microalbumin < 300 mg/day
- •Body mass index (BMI) < 35 kg/m2
排除标准
- •Insulin-dependent diabetic patients
- •Patient with persistent microalbuminuria
- •Patient with history of severe hypertension
- •Congestive heart failure
- •Patient receiving renin-angiotensin-aldosterone system (RAAS)-related anti-hypertensive medications.
- •Patient with major hepatic disease
结局指标
主要结局
ACE and ACE2 activities in monocytes
次要结局
未报告次要终点
研究者
研究点 (1)
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