Evaluation of Ovarian Reserve Using Anti-müllerian Hormone and Antral Follicle Count in Ankylosing Spondylitis: Preliminary Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- anti-müllerian hormone (AMH)
研究概览
简要总结
The aim of this study was to determine the status of ovarian reserve in patients with ankylosing spondylitis (AS) using anti-mullerian hormone (AMH) level and antral follicle count (AFC). Women with AS and women controls diagnosed according to the classification criteria proposed by the American-European Consensus Group will be included in the study. Ovarian reserve will be evaluated in terms of clinical findings, AFC and serum AMH and reproductive hormone levels.
Researchers predict that the ovarian reserve may be reduced in patients with AS due to the autoimmune process and the pathophysiology of the disease. Serum AMH and ovarian AFC may be useful for assessing ovarian reserve. It is aimed to determine the course of ovarian reserve abnormalities and the best possible biomarkers of reduced ovarian reserve in patients with AS.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •regular menstruation with intervals of 21-35 days;
- •cycle length variations <4 days;
- •both ovaries still present
排除标准
- •history of liver failure;
- •diagnosed malignancy;
- •cigarette smoking;
- •chronic renal failure;
- •known infertility;
- •presence of gynecological abnormalities such as abnormal uterine bleeding or menorrhagia;
- •history of ovarian surgery;
- •history of hormone preparation (including corticosteroids) use or use of herbal products within 3 months;
- •diagnosis of polycystic ovary syndrome.
结局指标
主要结局
anti-müllerian hormone (AMH)
时间窗: 3 days
For ovarian capacity AMH will be examined and AMH levels will be recorded in pmol/l
antral follicle count (AFC)
时间窗: 1 day
For ovarian capacity AFC will be examined and It will be recorded as a NUMBER.
次要结局
未报告次要终点
研究者
Pınar Kadirogulları
Principal investigator, Pınar kadirogullari, M.D, Department of Obstetrics and Gynecology
Kanuni Sultan Suleyman Training and Research Hospital