ISRCTN13479086进行中（未招募）未知
Sex differences in the role of sympathetic nerve activity in the development of hypertension in humans
niversity of Bristol0 个研究点目标入组 148 人开始时间: 2019年6月28日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 148
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •1. Aged 18-75 years
- •2. Hypertensive patients: Office blood pressure = 140/90 mmHg and daytime ambulatory blood pressure =135/85 mmHg
- •3. Normotensive participants: Office blood pressure < 140/90 mmHg and daytime ambulatory blood pressure < 135/85 mmHg
- •4. Postmenopausal women: No period for at least 12 months and not using hormonal contraception (NICE, 2015)
排除标准
- •1. Secondary causes of hypertension
- •2. Body mass index > = 30 kg/m2
- •3. Oophorectomy (removal of ovaries) prior to onset of natural menopause
- •4. Pregnancy/breastfeeding women
- •5. Taking hormone replacement therapy
- •6. Taking nitrate, steroid, anti-coagulant or immunosuppressant medication or medication as part of a clinical trial
- •7. Major illness e.g. cancer, inflammatory disease (including vasculitis) or receiving palliative care
- •8. Diagnosed cardiovascular (including arrhythmia), respiratory (including asthma), psychiatric, renal or ophthalmic disease
- •9. Congenital or acquired neurological conditions (including dementia), language disorders, repeated or chronic pain conditions (excluding menstrual pain and minor sporadic headaches)
- •10. Diabetes
- •11. Symptoms of febrile illness less than a week before experiment
- •12. Excessive alcohol consumption (> 28 units/week) or use of illicit drugs
- •13. Needle phobia
- •14. Inability to understand instructions given in English
- •15. Mild, moderate or severe persistent asthma (due to potential broncho effects of a systemic beta-blocker)
- •For premenopausal women and younger men only (relating to the propranolol infusion):
- •1. Individuals with any of the conditions listed in the instructions for use document of Dociton solution of injection (propranolol hydrochloride) in which Dociton must not be used:
- •1.1. Hypersensitivity to propranolol/beta-blockers or other ingredients in Dociton
- •1.2. Heart muscle weakness
- •1.3. Shock
- •1.4. Grade II or III AV block
- •1.5. Sick sinus syndrome
- •1.6. Sino-atrial block
- •1.7. Bradycardia (resting pulse < 50 beats/min)
- •1.8. Hypotension
- •1.9. Acidosis
- •1.10. Taking MAO inhibitors
- •1.11. Late stage peripheral blood flow disorders
- •1.12. tendency towards bronchial spasm e.g. bronchial asthma.
- •2. Individuals with any condition listed in the instructions for use document in which Dociton should be used with caution:
- •2.1. Grade I AV block
- •2.2. Diabetes mellitus
- •2.3. Lengthy strict fasting and severe physical stress
- •2.4. Phaeochomocytoma
- •2.5. Impaired liver or kidney function
- •2.6. Individual/family history of psoriasis
- •2.7. History of severe hypersensitivity reaction or receiving treatment to weaken allergic reactivity).
- •3. Individuals taking/recently taken any medication listed in the instructions for use document as being affected by Dociton or affecting Dociton:
- •3.1. Insulin/oral antidiabetics
- •3.2. Other blood pressure-lowering medications, nitroglycerin, diuretics, vasodilators, tricyclic antidepressants, phenothiazines, barbituates
- •3.3. Calcium antagonists of the nifedipine type
- •3.4. Calcium antagonists of the verapamil or diltiazem type
- •3.5. Antiarrhythmics, e.g. disopyramine or others
- •3.6. Cardiac glycosides
- •3.7. Reserpine
- •3.8. Alpha-methyldopa
研究者
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