The effect of Vitamin D3 to prevent postoperative relapse of Crohn*s Disease: a placebo-controlled randomized trial (DETECT) - DETECT

Academisch Medisch Centrum0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•- Age * 18 years, either male or female
•- Established CD
•- First or second ileocolonic resection with ileocolonic anastomosis and removal of all tissue macroscopically affected by CD according to the surgeon
•- Able to give written informed consent
•- Normal levels of serum calcium at inclusion, corrected for albumin
•- Being able to resume oral intake within 2 weeks after surgery

•- Patients in whom not all visible CD has been resected
•- Active fistulizing perianal disease (requiring anti TNF treatment)
•- Extensive small bowel resection
•- Third, fourth or later ileocolonic resection
•- Patients undergoing ileocoecal resection in the Lir!c Trial (NTR 1150, http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1150)
•- A history of primary hyperparathyroidism
•- A history of osteoporosis for which calcium and Vitamin D treatment are mandatory
•- A history of another granulomatous diseases (sarcoïdosis, tuberculosis)
•- Pregnant or breastfeeding (at index date) female patients
•- Patients undergoing other resections than ileocolonic resections
•- Patients who prefer to use open-label vitamin D preparations

发起方