The Acute Effects of Liquid IV's Multi-Ingredient Pre-Workout Supplement, on Endurance, Strength, Energy, and Cognition: A Randomized Crossover Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Aerobic Endurance (Graded Cycling Test VO₂max )
研究概览
简要总结
The goal of this study is to learn if a new pre-workout supplement can improve exercise performance in healthy adults. It will also look at how the supplement affects mood and energy levels.
The main questions it aims to answer are:
Does the pre-workout supplement improve endurance and strength during exercise?
Does it reduce how hard exercise feels (perceived exertion)?
How does it affect participants' mood and energy?
Researchers will compare the pre-workout supplement to a placebo (a look-alike powder that contains no active ingredients) to see if it works.
Participants will:
Take the pre-workout supplement or a placebo before exercise in two separate sessions;
Complete exercise tests after taking each one;
Report how they feel during and after exercise, including mood, energy, and effort.
By bridging gaps in existing research, this study aims to establish a robust scientific foundation for the application of this novel pre-workout supplement in enhancing exercise outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy males or females aged 18-55
- •Must be recreationally trained or trained/developmental as previously defined (McKay et al., 2021)
- •Able to read and write in English
- •Willing to maintain their regular supplement routine during the study (other than what is listed in
排除标准
- •Are not consistently taking, or will discontinue consuming other pre-workout supplements or dietary supplements, such as creatine, rhodiola, L-Theanine, glycerol, stimulants other than caffeine, or ingredients which may promote hydration or enhance physical performance within the past 2-weeks, and throughout the duration of the study.
- •Willing to restrict caffeine for 24 hours prior to testing
- •Will not participate in any strenuous exercise for a minimum of 72 hours prior to exercise performance assessments. Strenuous exercise as defined for this study includes ½ and full marathons (or more), heavy (i.e.,>80% 1RM) lifting, and any high intensity, physical activity that could make your muscles sore.
- •Exclusion Criteria:
- •Sedentary: Individuals performing less than 150 minutes of moderate or 75 minutes of vigorous activity per week and engaging in resistance training fewer than 2 days per week, with no structured exercise routine.
- •Highly trained/national level or professional athlete: Individuals training ≥5 days per week in structured programs, including NCAA Division II/III athletes, national/professional competitors, or those targeting top 20% sport-specific performance norms.
- •Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease
- •Recent musculoskeletal injury (<3-months)
- •Recent orthopaedic surgery (<12-months)
- •History or current malignancy
- •Previous gastrointestinal surgery within the past 12 months
- •Regular smoker
- •Regular drinker (>14 drinks per week)
- •Current respiratory infection (i.e. cold) or high temperature (fever) within the past 4-weeks
- •Presently using GLP-1 medications
- •Individuals with cardiovascular, metabolic, or musculoskeletal disorders;
- •Those regularly using anti-inflammatory drugs within the last 4-weeks
- •Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)
- •Current consistent chronic use (within the past 2 weeks) of creatine, rhodiola, L-Theanine, glycerol, or other products which contain any of these ingredients.
- •Current consistent chronic use (within the past 2 weeks) of stimulants other than caffeine
- •Current consistent chronic use (within the past 2 weeks) of ingredients that may promote hydration or enhance physical performance.
- •Allergies to study-related materials
- •Any condition that may impair their ability to complete the required exercises (determined during screening).
- •Female subjects must not be pregnant or lactating
- •Are unable to provide informed consent or are non-English speakers.
研究组 & 干预措施
proprietary pre-workout supplement
Liquid IV pre-workout supplement powder
干预措施: proprietary pre-workout supplement (Dietary Supplement)
Control treatment
inactive/inert placebo mixture
干预措施: Control placebo (Dietary Supplement)
结局指标
主要结局
Aerobic Endurance (Graded Cycling Test VO₂max )
时间窗: From baseline 70 minutes after treatment consumption, then again on day 6, 70 minutes post treatment consumption
Participants will complete a graded cycling test on a calibrated cycle ergometer to assess aerobic performance. Maximal oxygen consumption (VO₂max) will be noted if a plateau is observed. using a metabolic cart to determine VO₂max.VO₂max represents the highest rate of oxygen consumption achieved during the test. Proper cycle ergometer setup, including seat height and handlebar position, will be standardized for all participants. Testing will be conducted by trained technicians for consistency.
Local Muscular Endurance (Bench Press to Failure)
时间窗: From baseline 50 minutes post treatment consumption, then again on day 6, 50 minutes post treatment consumption
Participants will complete bench press assessments to evaluate muscular strength and endurance. A 5-repetition maximum (5RM) protocol will be used to determine maximal bench press strength. For muscular endurance, participants will complete two sets of bench press at 60% of their 1RM, performing repetitions to fatigue with 2 minutes of rest between sets. Total work volume will be calculated as the product of sets × repetitions. Proper spotting and form supervision will be ensured throughout.
Aerobic Endurance (Graded Cycling Test VO₂peak)
时间窗: From baseline 70 minutes after treatment consumption, then again on day 6, 70 minutes post treatment consumption
Participants will complete a graded cycling test on a calibrated cycle ergometer to assess aerobic performance. Oxygen consumption (VO₂) will be continuously monitored every 15 seconds using a metabolic cart to determine VO₂peak. Peak oxygen consumption will be recorded as the highest oxygen uptake value observed during the incremental test. Proper cycle ergometer setup, including seat height and handlebar position, will be standardized for all participants. Testing will be conducted by trained technicians for consistency.
Aerobic Endurance (Graded Cycling Test Time to Exhaustion)
时间窗: From baseline 70 minutes after treatment consumption, then again on day 6, 70 minutes post treatment consumption
Participants will complete a graded cycling test on a calibrated cycle ergometer to assess aerobic performance. The total duration in minutes participants are able to sustain the incremental cycling workload until volitional fatigue is recorded. This measures endurance capacity during the graded test. Proper cycle ergometer setup, including seat height and handlebar position, will be standardized for all participants. Testing will be conducted by trained technicians for consistency.
Aerobic Endurance (Graded Cycling Test Total Work Performed)
时间窗: From baseline 70 minutes after treatment consumption, then again on day 6, 70 minutes post treatment consumption
Participants will complete a graded cycling test on a calibrated cycle ergometer to assess aerobic performance. Total work (kJ) will be calculated as Σ(power × time)/1000, where power = kp × 50 RPM × 6.118.. This reflects overall exercise performance. Proper cycle ergometer setup, including seat height and handlebar position, will be standardized for all participants. Testing will be conducted by trained technicians for consistency.
次要结局
- Thayer Activation-Deactivation Adjective Checklist (ADACL)(From baseline, 10 minutes pre treatment consumption, then 35 minutes after treatment consumption, and then again 90 minutes post treatment consumption. Until repeated on day 6.)
- Samn-Perelli Visual Analog Scale (VAS)(From baseline, 10 minutes pre treatment consumption, then 35 minutes after treatment consumption, and then again 90 minutes post treatment consumption. Until repeated on day 6.)
- Caffeine Visual Analog Scale (VAS)(From baseline, 10 minutes pre treatment consumption, then 35 minutes after treatment consumption, and then again 90 minutes post treatment consumption. Until repeated on day 6.)
- Muscle Strength and Strength Endurance (Isometric Mid Thigh Pull)(From baseline 40 minutes after treatment consumption, then again on day 6, 40 minutes post treatment consumption)
- Lower Body Power and Force Generation (Maximal Countermovement Jump)(From baseline 45 minutes after treatment consumption, then again on day 6, 45 minutes post treatment consumption)
- Body Hydration Bioelectrical Impedance Analysis (InBody)(From baseline, 20 minutes pre treatment consumption, then 30 minutes after treatment consumption, and then again 100 minutes post treatment consumption. Until repeated on day 6.)
- Muscle Strength and Endurance (Grip Strength)(From baseline 35 minutes post treatment consumption, then again on day 6, 35 minutes post treatment consumption)
- Body Hydration (Urine Specific Gravity)(From baseline, 20 minutes pre treatment consumption, then again 100 minutes post treatment consumption. Until repeated on day 6.)