Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently.
研究概览
简要总结
Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.
详细描述
Prospective observational clinical multicentric study on ICU ventilated patients requiring chest ultrasound analysis during weaning from mechanical ventilation with 48 hours of follow-up. Studying variations of cardiac markers
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Adult patients ventilated more than 48 h
- •Stable respiratory and hemodynamic conditions for SBT
- •Consent of patients
- •Arterial line
排除标准
- •Laryngeal dyspnea
- •Tracheostomy
- •No echogenicity
- •Paraplegia >T8
研究组 & 干预措施
patients requiring ventilation
patients who weaned permanently
结局指标
主要结局
Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently.
时间窗: before, at the end, and 4-6 h after
Compare the change in pulmonary aeration during the test of weaning from mechanical ventilation (before, at the end, and 4-6 h after) between patients requiring re-ventilation before the 48th hour, and those weaned permanently.
次要结局
- Compare the variations of lung ultrasound score during the test of the weaning from mechanical ventilation between patients failed the spontaneous breathing test (SBT) and those extubated after successful SBT.(in the 4-6 early hours)
- Constitution serum bank for epithelial (sRAGE) markers dosages(at h0, h1, h4, h6)
- constitution serum bank for endothelial (angiopoietin) markers dosages(at h0, h1, h4, h6)
- Studying variations, during weaning from mechanical ventilation, of pressure of left ventricle filling (E / Ea) coupled with those of plasma BNP.(in the 4-6 early hours)
- Assessing the effects of E / Ea and BNP variations on the success or failure in the 4-6 early hours.(in the 4-6 early hours.)
- Comparison of levels epithelial and endothelial markers(at h0, h1, h4, h6)