The Clinical Effectiveness of Hydroxylated Polymethoxy Flavones Solid Dispersion as a Dressing Material for Palatal Graft Donor Sites
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- post operative pain (VAS scale)
研究概览
简要总结
Free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . The donor sites pain , infection and retarded healing by secondary intension are the complication .
详细描述
After the preparation and characterization of the solid dispersion of hydroxylated methoxy flavones, free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . The donor sites pain , infection and retarded healing by secondary intension are the complications ; the aim of the study is to assess the analgesic , anti inflammatory effects of hydroxylated methoxy flavones.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •insufficient zone of keratinized gingiva recession of the gingiva non smokers free from systemic disorders
排除标准
- •smokers insufficient palatal donor sits un realistic expectations
研究组 & 干预措施
hydroxylate flavones
flavonoids mainly derived from citrus peel and have numerous strong biological activities, including anti-inflammatory , antioxidant , antimicrobial , and anticancer
干预措施: hydroxylate flavones solid dispersion application (Drug)
hydroxylate flavones
flavonoids mainly derived from citrus peel and have numerous strong biological activities, including anti-inflammatory , antioxidant , antimicrobial , and anticancer
干预措施: Placebo (Other)
alveogyl
ALVOGYL is a brown fibrous paste which contains per 100 g the following active ingredients : 25.70 g of butamben, 15.80 g of iodoform and 13.70 g of eugenol.
干预措施: hydroxylate flavones solid dispersion application (Drug)
alveogyl
ALVOGYL is a brown fibrous paste which contains per 100 g the following active ingredients : 25.70 g of butamben, 15.80 g of iodoform and 13.70 g of eugenol.
干预措施: Placebo (Other)
stent
acrylic resin material used to cover denuded soft tissues
干预措施: hydroxylate flavones solid dispersion application (Drug)
结局指标
主要结局
post operative pain (VAS scale)
时间窗: first day postoperative to 30 days (days)
VAS scale from 0 no pain to 10 excruciating pain (healing)
次要结局
- Number of analgesic and anti inflammatory pills consumed(first day postoperative to 30 days (days))
研究者
Ahmed Mortada
associate professor - faculty of dentistry
Assiut University