Placental Inflammation in Prenatal Care
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- Inflammatory markers (CRP, IL-6) of cord blood
研究概览
简要总结
Objective of study is to explore expression of stress-related genes and inflammation in placentas and umbilical cord blood for women participating in group prenatal care compared with women receiving individual prenatal care.
详细描述
This study aims to evaluate levels of inflammatory markers and genetic indicators of stress an inflammation in the placentas and umbilical cord blood in pregnancies that undergo group prenatal care as compared to traditional prenatal care. The investigators know that women receiving group prenatal care have fewer spontaneous preterm deliveries. What is not known is the mechanism behind this difference. By collecting umbilical cord blood samples and placentas of 40 women at the time of delivery, the investigators hope to study expression of stress-related genes and levels of inflammatory markers at the maternal-fetal interface.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age >= 18 years
- •Singleton pregnancy
排除标准
- •Presence of known fetal congenital anomalies (lethal anomaly or anomalies that may lead to early delivery or increased risk of neonatal death).
- •Presence of known chromosomal abnormalities
- •Progesterone treatment during the current pregnancy after 14 weeks
- •Chronic corticosteroid (i.e. Prednisone or other steroids) treatment during the current pregnancy (not including inhalers or topical)
结局指标
主要结局
Inflammatory markers (CRP, IL-6) of cord blood
时间窗: drawn from the umbilical cord within 15 minutes of delivery
Circulating concentrations of C-reactive protein and interleukin-6 will be quantified in serum harvested from umblical blood
次要结局
- Genome wide expression profiling of cord blood(drawn from the umbilical cord within 15 minutes of delivery)