S8600-S9031-S9333-A, Identification of Differentially Methylated Genomic Regions That Are Prognostically Significant in AML
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 主要终点
- Prognostic score able to group AML patients into risk groups
研究概览
简要总结
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients respond to treatment.
PURPOSE: This research trial studies DNA in samples from patients with acute myeloid leukemia.
详细描述
OBJECTIVES:
- To identify differentially methylated regions (DMRs) associated with overall survival (OS) of acute myeloid leukemia (AML) patients with normal cytogenetics.
- To develop and evaluate in an independent validation set a prognostic score for OS based on the identified DMR.
- To determine whether the prognostic score can group patients into risk groups based on OS.
OUTLINE: Archived blood or bone marrow samples are analyzed for DNA methylation alterations by CHARM array-based genome assay. Each patient's clinical data is also collected.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Prognostic score able to group AML patients into risk groups
时间窗: immediate
Development and evaluation of a prognostic score of OS based on DMRs identified
时间窗: immediate
Identification of DMRs associated with OS
时间窗: immediate
次要结局
未报告次要终点