Molecular Characterization of Neuroblastic Tumor: Correlation With Clinical Outcome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,070
- 试验地点
- 1
- 主要终点
- To study the molecular-genetic makeup and metastasis of neuroblastic tumors.
研究概览
简要总结
The purpose of this study is to find out the genetic and biochemical makeup of your neuroblastic tumor, which influences its aggressiveness and the suitable therapy. These research studies include surface marker analysis, cytogenetics, cancer genes,genome sequencing, tumor growth-related genes and tumor growth in test tubes. Your blood, marrow, and hematopoietic stem cell samples will also be tested for tumors or leukemia cells, and your serum tested for anti-tumor antibodies.
详细描述
To collect tumor, marrow specimens prospectively to study the molecular-genetic makeup of individual neuroblastic tumor and its metastasis by blood and marrow, and to correlate these findings with clinical outcome, and to relate the signaling circuitry of neuroblastic tumors to that of embryonic neuroectodermal cells. .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Neuroblastic tumors diagnosed in accordance with the International Neuroblastoma Staging System
- •Clinically suspected neuroblastic tumors.
- •PK DRAW INCLUSION CRITERIA (FOR PK DRAWS ONLY):
- •PK Draw Inclusion Criteria
- •Patients who receive naxitamab as part of their standard of care
排除标准
- 未提供
结局指标
主要结局
To study the molecular-genetic makeup and metastasis of neuroblastic tumors.
时间窗: 2 years
Before surgery a maximum of 5 blood drawings (20-30 ml) will be performed per year (at least one month apart) per patient
次要结局
- To study the correlation of these biologic markers with clinical outcome.(2 years)
- To relate neuroblastic tumor and embryonic neuroectodermal cell circuitry.(2 years)