Effect of Heated Breathing Circuit on Intraoperative Core Temperature and Systemic Inflammation After Brain Surgery: a Prospective Randomized Study
试验速览
- 阶段
- 不适用
- 入组人数
- 117
- 试验地点
- 2
- 主要终点
- core temperature
研究概览
简要总结
Mechanical respiration during general anesthesia causes cold and dry gases to reach the lower airway, reduce the function of the airway mucosa, and cause accumulation of secretions. Inhaled dry gas is one of the causes of hypothermia during general anesthesia. To overcome this, the warm-humidifying breathing circuit uses warm, moisture-preserving gas to promote mucus mobility of the airway mucosal ciliate cells and prevents cold gases from evaporating from the mucosal surfaces which results lowering body temperature. We aimed to investigate the effect of newly developed Sohum warm humidifying respiration circuit (SH501) on the prevention of core body temperature reduction during surgery and systemic inflammation reaction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for brain surgery
排除标准
- •patients with severe obstructive lung disease and/or restrictive lung disease patients
- •patients with infectious disease
- •surgery with prone position or lateral position
研究组 & 干预措施
group C
general circuit group
干预措施: conventional circuit (Device)
group H
warm circuit group
干预措施: conventional humidification circuit (Device)
group SH
new warm circuit group
干预措施: new humidifaction heat circuit (Device)
结局指标
主要结局
core temperature
时间窗: every 30 minute after induction of anesthesia until the end of anesthesia
upper airway humidity
时间窗: every 30 minute after induction of anesthesia until the end of anesthesia
upper airway temperature
时间窗: every 30 minute after induction of anesthesia until the end of anesthesia
次要结局
- respiratory variables(every 30 minute after induction of anesthesia until the end of anesthesia)
- intrapulmonary shunt(every 30 minute after induction of anesthesia until the end of anesthesia)
- compliance(every 30 minute after induction of anesthesia until the end of anesthesia)
- cytokine level(1, 30, 60, 90, 120, 150, 180, 210, 240 minute after induction and 1 second after the operation)
- dead space(every 30 minute after induction of anesthesia until the end of anesthesia)