NL-OMON33343已完成不适用
The effects of iron loading and iron chelation during human endotoxemia. - iron loading and iron chelation during human endotoxemia.
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 54 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age >= 18 and <= 35 yrs
排除标准
- •- Use of any medication or anti-oxidant vitamin supplements
- •- History of allergic reaction to iron preparations or iron chelators.
- •- History of frequent vaso-vagal collapse
- •- History, signs or symptoms of cardiovascular disease
- •- (Family) history of myocardial infarction or stroke under the age of 65 years
- •- Cardiac conduction abnormalities on the ECG consisting of a 1st degree atrioventricular block or a complex bundle branch block.
- •- Hypertension (defined as RR systolic > 160 or RR diastolic > 90)
- •- Hypotension (defined as RR systolic < 100 or RR diastolic < 50)
- •- Renal impairment (defined as plasma creatinin >120 µmol/l)
- •- Liver enzyme abnormalities or positive hepatitis serology
- •- Subjects with elevated bilirubin levels >20 umol/l
- •- Dyslipidemia or elevated glucose level
- •- Positive HIV serology
- •- Immune deficiency
- •- Febrile illness in the week before the LPS challenge
- •- Participation in a drug trial or donation of blood 3 months prior to the LPS challenge
- •- Participation in a previous study in which LPS was administered.
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