Investigation of platelet function and formation of platelet-leukocyte aggregates during initial antiretroviral therapy of HIV-infected adults over 48 weeks - HIV-PLAII

HIVCENTERMedizinische Klinik IIKlinikum der J. W. Goethe-Universität0 个研究点目标入组 50 人开始时间: 2010年2月17日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•patients with assured HIV-1-infection
•- therapy-naive patients; patients that took ART (antiretroviral therapy) medication for not longer than two weeks in context with a clinical study more than 3 months before inclusion into this observational study, should be regarded as therapy-naive, too.
•- treated ambulantly or in hospital
•- written informed consent

•- neurological diseases, influencing the patients? cognition
•- manifest psychoses and/or severe psychiatric diseases that seem to interfere with the patients? comprehension for the sense, risk and needs of this study
•- apparent limitations of compliance due to addiction to, drugs or pharmaceuticals
•- haemoglobin < 10g/dl in men or < 8g/dl in women, respectively
•- thrombocytopenia with < 50.000 platelets/µl blood
•- known and untreated blood coagulation disorders
•- diabetes
•- untreated hypertension with a systolic/diastolic blood pressure of > 140/90
•- cholesterol plasma levels of > 250mg/dL
•- body mass index (BMI) > 35
•- strong smokers with a consume of more than 10 cigarettes daily
•- intake of non steroidal anti inflammatory drugs (NSAIDs) like diclofenac, acetylsalicylic acid (ASA) etc. less than 7 days before the screening date
•- intake of oral anticoagulants, inhibitors of platelet aggregation like clopidogrel, acetylsalicylic acid (ASA) and dipyridamole

发起方

HIVCENTERMedizinische Klinik IIKlinikum der J. W. Goethe-Universität