Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation in Hypoxic Ischemic Brain Injury After Cardiac Arrest
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Cerberal blood flow
研究概览
简要总结
Hypoxic ischemic brain injury is a devastating illness that occurs after cardiac arrest (the heart stopping) and can yield irreversible brain damage, often leading to death. The mainstay in therapy is to optimize the delivery of oxygen to the brain to help it recover. In patients with traumatic brain injury (similar to HIBI), the investigators are able to optimize oxygen delivery to the brain with the use of wires placed into the brain that sense the pressure and oxygen in the skull to find the ideal blood pressure for each individual patient. This strategy is associated with improved outcomes. The investigators are conducting a prospective study investigating whether the perfusion within proximity to the optimal MAP is associated with improved brain oxygenation and blood flow .
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed cardiac arrest with return of spontaneous circulation > 10 minutes
- •post resuscitation GCS < 9
排除标准
- •concurrent coagulopathy
- •prior history of TBI, intracranial hemorrhage, subarachnoid hemorrhage
- •anticipated cardiac catheterization within next 7 days
- •anticipated or current use of anticoagulants or anit-platelets
结局指标
主要结局
Cerberal blood flow
时间窗: 12 hours
mls/100g/min
次要结局
未报告次要终点
研究者
Myp Sekhon
Principal Investigator
University of British Columbia
