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临床试验/NCT03609333
NCT03609333已完成不适用

Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation in Hypoxic Ischemic Brain Injury After Cardiac Arrest

University of British Columbia2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2016年11月12日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
20
试验地点
2
主要终点
Cerberal blood flow

研究概览

简要总结

Hypoxic ischemic brain injury is a devastating illness that occurs after cardiac arrest (the heart stopping) and can yield irreversible brain damage, often leading to death. The mainstay in therapy is to optimize the delivery of oxygen to the brain to help it recover. In patients with traumatic brain injury (similar to HIBI), the investigators are able to optimize oxygen delivery to the brain with the use of wires placed into the brain that sense the pressure and oxygen in the skull to find the ideal blood pressure for each individual patient. This strategy is associated with improved outcomes. The investigators are conducting a prospective study investigating whether the perfusion within proximity to the optimal MAP is associated with improved brain oxygenation and blood flow .

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Confirmed cardiac arrest with return of spontaneous circulation > 10 minutes
  • post resuscitation GCS < 9

排除标准

  • concurrent coagulopathy
  • prior history of TBI, intracranial hemorrhage, subarachnoid hemorrhage
  • anticipated cardiac catheterization within next 7 days
  • anticipated or current use of anticoagulants or anit-platelets

结局指标

主要结局

Cerberal blood flow

时间窗: 12 hours

mls/100g/min

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Myp Sekhon

Principal Investigator

University of British Columbia

研究点 (2)

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